The focus of the Research Priority Area Systems Biology is on Host-Microbiome Interactions divided over various sub-themes. It is a collaboration of research groups in SILS and IBED.
Systems biology has become an intrinsic part of contemporary life-science research. It is based on the notion that to better understand the complexity of biological systems, these should be considered as a whole. Hence, the different intricate components of any living system ought to be studied and contextualized with a combination of experimental and theoretical approaches. This type of research, given its multidisciplinary nature, needs to be executed in collaborative efforts, integrating many scientific disciplines, such as biology, mathematics, physics, biochemistry, bioinformatics, computer science and so on. The main focus is to acquire a (quantitative) understanding of how biological systems change over time and respond to changing conditions.
The subthemes of Systems Biology are:
Next to an overlap by focussing on host-microbiome interactions in different organisms or environments, all subthemes make use of generic modelling and data analysis. This encompass methods to combine top-down and bottom-up systems biology methods such as:
For more information from the research groups themselves, check their website: systemsbiology.amsterdam.