Limiting ischemia-reperfusion injury
Ischemia is caused by insufficient blood supply to a tissue, and can occur in the heart when a coronary artery becomes blocked. Reperfusion, i.e. restoration of blood flow, prevents infarction of the total area, but cannot prevent enlargement of the infarct into the risk area. This is known as reperfusion injury. Willeke Jong studies the different processes that occur during ischemia and reperfusion, focusing specifically on the factors that are released over time. The aim is to use these insights to limit reperfusion injury.
W.M.C. Jong: Inflammation and Acute Myocardial Ischemia-Reperfusion Injury using a Closed-Chest Mouse Model.
Prof. M.W. Hollmann
Prof. R.J. de Winter
Prof. H. ten Cate (Maastricht University)
Dr C.J. Zuurbier
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