Inhibiting signaling in B cell malignancies
B cells are lymphocytes that express and produce antibodies. The malignant counterparts of B cells, B cell leukemias and lymphomas, imitate the homing and migration behaviour of their non-malignant cells of origin. Signaling plays a crucial role in the growth, homing and retention of malignant B cells Martin van Rooij describes the molecular details of these signaling pathways, together with promising drugable targets of these pathways, which can be used to treat B cell malignancies.
M.F.M. de Rooij: Targeting the BCR Signalosome in B Cell Malignancies.
Prof. S.T. Pals
Dr M. Spaargaren
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